From Tampa Airport take Interstate 275 South through St Petersburg, over the Sunshine skyway bridge.  About a mile after the bridge, exit on Highway 19.  Follow Highway 19 to Highway 41.  Highway 41 splits into a business route and a by-pass route, stay left (not the business route).   Continue on Highway 41 across the Manatee river and into Bradenton.  Turn right on Manatee(64) two blocks past the river.  

The trip from the airport takes from 1 to 1 1/2 hours in normal traffic